Scientist »Dr. Srujan Marepally

Srujan Marepally  

Contact

Laboratory of Nanobioscience and Nanobiotechnology
Centre for Stem Cell Research
Christian Medical College

Office: +91 416 307-5131
Lab: +91 416 307-5132
Fax: +91 416 307-5103
Email: srujankm@cmcvellore.ac.in

Career Interests

Biomaterials for nucleic acid delivery,
Understanding the mechanisms involved in lipid mediated transfections,
Developing next generation therapeutics for autoimmune disorders such as psoriasis, inflammatory bowel disease (IBD) and vitiligo,
Developing toolsets for CRSIPR/Cas9 based genome editing.

Education

  • 2013-2015: DST-SERB young investigator/senior research associate at institute for stem cell biology and regenerative medicine, Bengaluru.
  • 2011-2013: Post-doctoral research associate in College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, USA.
  • 2005-2011: Ph.D. in Chemistry, Indian Institute of Chemical Technology, Hyderabad, India.
  • 2002-2004: Master of Science (M. Sc.) Degree in Chemistry, Osmania University, Hyderabad, India.
  • 2000-2002: Master of Science (M. Sc.) Degree in Zoology, Osmania University, Hyderabad, India.

Awards

  • Travel award from American Association for Pharmaceutical Sciences (AAPS-2013) under biotech section.
  • Dr. K.V. Rao Young Scientist award in the field of Chemistry and allied sciences for the year of 2009.

Research

Our research is an interdisciplinary with an interface of chemistry and biology, emphasizes on lipid mediated gene therapy. Primary goal of our lab is to translate the concept of gene therapy to a clinically viable application. To this end, we are developing a library of lipids that can deliver nucleic acids efficiently both in vitro and in vivo. We are also focusing on understanding the mechanisms involved in lipid mediated transfections to overcome the major clinical limitations such as poor nucleic acid delivery efficiencies and cytotoxicities of nanocarriers. To increase the efficiency of the nanocarrier system, we are developing intrinsically active lipids for nucleic acids and drugs to enhance their efficacies in a synergistic manner. In the process, we aim to probe the mechanisms involved in lipofections. We are developing topical nucleic acid based therapeutics for autoimmune skin diseases such as psoriasis and vitiligo.

Gene therapy for psoriasis  

Lipids from vegetable oils

We also have collaboration with biologists to develop toolsets for efficient genome editing and reprograming of the cells.

With best regards!

Srujan Marepally

Research Fellows

Priya Dharmalingam

Priya Dharmalingam

Junior Research Fellow
E-mail: priyasuren20@gmail.com
Research Interests: Extracellular vesicles as a carrier system, Nanoparticles in Gene therapy and drug delivery.
Education: M.Tech. Medical Biotechnology, Dr. MGR Educational and Research Institute University.

Divyashree

Divyashree H B

Junior Research Fellow
E-mail: hbdivyashree@gmail.com
Research Interests: Ion channels role in lipid mediated gene delivery, epidermal immune regulating gene therapy for psoriasis.
Education: Integrated Master of Sciences in Biological Sciences, Bangalore University. (Gold Medalist and First Rank in Master of Sciences Bangalore University).

VigneshKumar Rangasami

VigneshKumar Rangasami

Junior Research Fellow
E-mail: vignesh.015@gmail.com
Research Interests: Application of Biomaterials in Tissue Engineering, Gene Therapy. Stem Cells in Regenerative Medicine.
Education: M.Sc. Molecular Medicine, Uppsala University, Sweden.

Selected Publications

  • Ambika S Kurbet, Samarth Hegde, Oindrila Bhattacharjee, Marepally S, Praveen K Vemula, Srikala Raghavan. Sterile inflammation enhances ECM degradation in integrin β1 KO embryonic skin. Cell Reports Volume 16, Issue 12, p3334–3347, 20 September 2016.
  • Andey T#, Marepally S#, Patel A, Jackson T, Sarkar S, O'Connell M, et al. Cationic lipid guided short-hairpin RNA interference of annexin A2 attenuates tumor growth and metastasis in a mouse lung cancer stem cell model. J Control Release. 2014; 184:67-78.
  • Marepally S#, Boakye CH#, Patel AR, Godugu C, Doddapaneni R, Desai PR, Singh M. Topical administration of dual siRNAs using fusogenic lipid nanoparticles for treating psoriatic-like plaques. Nanomedicine (Lond). 2014; 9(14) 2157-74.
  • Desai PR#, Marepally S#, Patel AR, Voshavar C, Chaudhuri A, Singh M. Topical delivery of anti-TNFalpha siRNA and capsaicin via novel lipid-polymer hybrid nanoparticles efficiently inhibits skin inflammation in vivo. J Control Release. 2013;170(1):51-63. PMCID: 3759511.
  • Srujan M, Chandrashekhar V, Reddy RC, Prabhakar R, Sreedhar B, Chaudhuri A. The influence of the structural orientation of amide linkers on the serum compatibility and lung transfection properties of cationic amphiphiles. Biomaterials. 2011;32(22):5231-40.
  • Mukthavaram R#, Marepally S#, Venkata MY, Vegi GN, Sistla R, Chaudhuri A. Cationic glycolipids with cyclic and open galactose head groups for the selective targeting of genes to mouse liver. Biomaterials. 2009;30(12):2369-84.
  • Rajesh M, Sen J, Srujan M, Mukherjee K, Sreedhar B, Chaudhuri A. Dramatic influence of the orientation of linker between hydrophilic and hydrophobic lipid moiety in liposomal gene delivery. J Am Chem Soc. 2007;129(37):11408-20.
  • (# Authors contributed equally)



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